Description
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Ketamine is a psychotropic drug used as an injectable anesthetic . It is also used as a pain reliever , sedative , and in veterinary medicine .
In the United States , it has been marketed since as an antidepressant under the name ” Spravato ” ( Janssen Laboratories ), in nasal spray . As of 2022, Spravato is in use in many countries.
From a pharmacological point of view , it is a dissociative amine that acts as a glutamate inhibitor at NMDA receptors , but its effect is mainly due to the consequence of blocking these receptors, namely the maintained activation of AMPA receptors . It is very close to phencyclidine (PCP) and resembles dextromethorphan at the pharmacological level.
It is part of the World Health Organization’s Model List of Essential Medicines (list updated in)
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Ketamine is also used recreationally for its strong psychodysleptic properties , particularly at rave parties . Generally, ketamine use is for the purpose of seeking a one-off experience. In Psychedelics , ketamine is being researched for its powerful antidepressant effect . The results were still incomplete (for obtaining marketing authorization for this indication) in 2017, despite efficacy indices dating back more than twenty years ; they are documented in more depth, and the American Food and Drug Administration ( FDA) and the European Regulatory Agency have approved them for the treatment of depression
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